Brain stimulation for intractable epilepsy: Anterior thalamus and responsive stimulation
نویسندگان
چکیده
منابع مشابه
Long-term anterior thalamus stimulation for intractable epilepsy.
BACKGROUND Deep brain stimulation (DBS) has re-emerged as an alternative therapy for intractable epilepsy. In this study, we investigated the feasibility, efficacy and safety of long-term anterior thalamic nucleus (ATN) stimulation for intractable epilepsy. METHODS In this open-label pilot study of electrical stimulation of the ATN, we investigated four cases of intractable epilepsy (one man ...
متن کاملElectrical stimulation of the anterior nucleus of the thalamus for the treatment of intractable epilepsy.
PURPOSE Animal studies and sporadic case reports in human subjects have suggested that intermittent electrical stimulation of the anterior nucleus of the thalamus reduces seizure activity. We embarked on an open-label pilot study to determine initial safety and tolerability of bilateral stimulation of the anterior nucleus of the thalamus (ANT), to determine a range of appropriate stimulation pa...
متن کاملAnticonvulsant serotonergic and deep brain stimulation in anterior thalamus
OBJECTIVE Anterior thalamus (AN) has been shown to mediate seizures in both focal and generalized models. Specific regional increase in AN serotonergic activity was observed following AN-DBS in our pentylenetetrazol (PTZ) rodent model of acute seizures, and this increase may inhibit seizures and contribute to the mechanism of anticonvulsant DBS. METHODS Anesthetized rats with AN-directed dial...
متن کاملBrain Stimulation for Epilepsy
Ignited by the efficacy and commercial success of cardiac devices, neurologists, neurosurgeons, and biomedical engineers are collaborating to develop implantable brain devices to arrest, contain, and preempt seizures before they cause clinical symptoms. New devices in development deliver electrical stimulation or pharmacologic agents locally to the epileptic focus or deep nuclei to modulate sei...
متن کاملResponsive cortical stimulation for the treatment of medically intractable partial epilepsy.
OBJECTIVES This multicenter, double-blind, randomized controlled trial assessed the safety and effectiveness of responsive cortical stimulation as an adjunctive therapy for partial onset seizures in adults with medically refractory epilepsy. METHODS A total of 191 adults with medically intractable partial epilepsy were implanted with a responsive neurostimulator connected to depth or subdural...
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ژورنال
عنوان ژورنال: Annals of Indian Academy of Neurology
سال: 2014
ISSN: 0972-2327
DOI: 10.4103/0972-2327.128671